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Go Directly to our #1 Recommendation for Fast Gout Relief
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"Facts About Probenecid" |
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What Exactly is Gout?
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Gout is caused by the buildup of too much uric acid in the blood. It is a normal function of the body, however, to get rid of this uric acid accumulation, which causes pain, swelling, redness, warmth, stiffness, and inflammation in a joint or multiple joints, though usually at different times and stages.
Gout, moreover, commonly occurs in middle aged men, in their 40s and 50s. Though genes are sometimes to blame, lack of exercise and proper diet are key factors in a gout attack, with this preliminary attack localized in the foot, primarily the big toe. Though gout attacks can vary from months to years, the exact causation factor still bewilders doctors, though most researchers blame poor diet and high purine foods.
In addition to medications (such as Celebrex and Probenecid) there are natural, diet oriented remedies that are extremely effective when it comes to long term management of Gout.
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What is Probenecid?
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A prescription medicine often used against the agitations of gout is Probenecid, sometimes referred to as Benemid or Probalan in the U.S. and Benemid or Benuryl in Canada. Though the kidneys and other regulatory waste systems of the body are supposed to remove uric acid naturally, Probenecid is primarily used in aiding in this removal of uric acid through urine extraction. Specifically, Probenecid reduces the amount of uric acid in the body by expelling more of such wastes through the urine. Oftentimes, Probenecid is used in conjunction with other antibiotics to increase effectiveness and absorption.
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How Does Probenecid Work?
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Probenecid is taken in the U.S. and Canada orally in tablet form. Probenecid essentially clings itself to purines and uric acid in the body and dispels it through the body’s natural kidney cleansing and urine extraction. Though used as a treatment, this medicine has not been proven to cure gout or gout attacks. However, it has been shown in clinical studies and reports to prevent re-occurring gout attacks, but only as long as the medicine is still present in the body. To a certain extent, the drug must be continually taken in order to work effectively against gout and future gout attacks.
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What is the History of Probenecid?
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When first tested, Probenecid was shown as not be effective for acute attacks of gout, generally aggravating inflammation during earlier stages. Approved by the FDA in 1951, the drug has been used in gout treatments for decades. What is currently known is that Probenecid impedes the tubular handling of organic acids in the nephron (part of kidney consisting of the glomerulus and its tubule). Furthermore, Probenecid inhibits the re-absorption of uric acid and thus facilitates in the decrease of plasma urate concentrations in the body. After taken, the drug is 75-95% plasma protein-bound.
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What are Common Side Effects of Probenecid?
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Because Probenecid has been around for so long, documented side effects of the drug are widening and varying. Though said to be uncommon and mild, kidney stones top the list when it is used for gouty arthritis. Other side effects associated with Probenecid are nausea, sore gums, hair loss, headache, skin rash, fever and intestinal pain. In some cases, severe anemia has been documented. Other less common but possible side effects listed by the FDA includes bloody urine, lower back or side pain, painful, cloudy or irregular urination.
Additionally, sores, ulcers, white spots in or on the mouth combined with a sore throat with or without chills have been documented as well. Some small cases of bruising, swollen face, fingers or feet along with yellow eyes or skin and weight gain accompanied by tiredness and weakness have been officially detailed during the initial stages of drug ingestion, though headache and loss of appetite are the most common side effects.
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What is Probenecid Dosage and Cost?
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Doctors prescribe Probenecid after determining a patient’s allergies, drug resilience, weight and height. For the onset of gout or reoccurring gout attacks, the usual dosage for adults is 250 mg (or half of a 500 mg tablet) two times per day for seven days. After which, the patient may consume up to 500 mg two times per day for two to three weeks. Future dosage will depend on the patient’s uric acid levels in the blood and urine. The average male requires 2-4 pills per day, though some take more or less depending on uric acid levels and recovery rate. The branded form of Probenecid costs roughly $80-150 USD for 100 tablets at 500 mg, while the generic form costs $40-100 USD for 100 tablets at 500 mg. |
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If you are looking for an easy, natural alternative to taking
Probenecid, Click Here |
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| Probenecid is manufactured and distributed by
ICN. |
| We are in no way associated or affiliated with the manufacturers or distributors of branded or generic form Probenecid. |
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