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Facts About Allopurinol

What Exactly is Gout?

Gout is caused by the proliferation of uric acid in the body, mainly in men either approaching or reaching middle age through the 60s (though it’s possible at any age). This uric acid comes from the body’s natural breakdown of purines, though pain sets in when these purines are left in the body and not dispelled naturally through the urine. The purines often settle as crystals in any number of the major joints of the body.

Those most likely people to contract gout are often hyperuricemia suffers: caused when the uric acid levels in the blood are too high. If you or your family members have a history of gout, are overweight, drink too much alcohol, eat purine-rich foods, exposed to a lead environment, have had an organ transplant, or have taken a wide range of diuretics, aspirin, cyclosporine or levodopa, then your odds of suffering the wretchedness of gout may be high.

The most effective way to gain fast and lasting gout relief is through a specific low-purine diet.

What is Allopurinol?

Allopurinol is used to treat patients who suffer chronic gout attacks. Essentially, it works by stopping the development of uric acid—a metabolic byproduct of protein present in the blood and expelled through the urine. By blocking the excessive buildup of uric acid, Allopurinol helps prevent future gout attacks. If patients have a history of gout, then Allopurinol can help prevent future gout attacks, but not treat gout once it has already occurred.

In fact, although possibly preventing future gout attacks, the first two to three months Allopurinol is taken, patients may suffer an increased number of gout attacks. Moreover, Allopurinol has no anti-inflammatory properties, with some doctors advising not to take the drug for treatment of acute gouty arthritis.

How Does Allopurinol Work?

Allopurinol is used to treat gout or for the treatment of high levels of uric acid in the major joints of the body. Allopurinol is in a class of medications referred to by doctors and pharmacists as a xanthine (xanthene) oxidase inhibitor, given to individuals going through chemotherapy or taking certain cancer medications or suffering from kidney stones.

Allopurinol is an isomer of hypoxanthine with the same chemical formula but with a different arrangement of atoms. Hypoxanthine is a naturally occurring purine in the body and discourages the small xanthine oxidase enzymes and ribotide purines from over production of uric acid. Allopurinol, consequently, diminishes both uric acid formation and purine synthesis but does strip the body of these harmful byproducts.

What is the History of Allopurinol?

Allopurinol has been widely available in the United States since 1964, and marketed by British based pharmaceutical, biological and healthcare provider GlaxoSmithKline (GSK) in the United States, branded as Zyloprim/Alloprim and available in a variety of other countries as Allohexal, Allosig, Progout, and Zyloric. Historically used to treat seizures, certain infections, reduce ulcer relapses, prevent bodily rejection to kidney transplants, and improve survival rates after bypass surgery, Allopurinol was only later used in the treatment of gouty arthritis.

What are Common Allopurinol Side Effects?

Allopurinol has both reported side effects, with some serious to life threatening, though rare. Allopurinol can cause upset stomach, diarrhea, drowsiness, indigestion, nausea, vomiting and itching. Additionally, Allopurinol may cause more serious side effects such as painful urination, bloody stools or urine, eye irritation, lip and mouth swelling, unexpected weight loss and (in patients with renal insufficiency) various types of skin rashes, fever, sore throat, infection and chills.

The most serious side effect occurring with Allopurinol are hypersensitivity syndromes compromising eosinophilia, hepatitis, Stevens-Johnson syndrome (SJS) and Toxic Epidermal Necrolysis Syndrome (TENS): Both SJS and TENS cause blistering of mucous membranes in the mouth, eyes, vagina and other patchy skin areas. The top epidermis layer of the skin often peels and the disorder can be life threatening.

What is Allopurinol Dosage and Cost?

Allopurinol comes in 100 mg pills and is often taken daily by gout suffers, though the medicine as suggested does not assist in removing uric acid wastes in the body, nor is it an anti-inflammatory. The drug is often prescribed in detouring possible gout attacks, though attacks may persist or increase in the first few months of ingestion. Some distributors offer a 300 mg variant of the pill, though it’s often only sold in the 100 mg dosage. Moreover, the costs can vary by country. In the United States, Allopurinol—both generic and branded sorts—sells for between $50 USD to $100 USD for 100 tablets.

For an easy, natural alternative to taking Allopurinol, Click Here

Allopurinol is marketed by GlaxoSmithKline (GSK) of Britain.
We are not associated with GlaxoSmithKline (GSK) or any of its affiliates.
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